Nine new cedrelone limonoids, namely, walsuranolide B, 11β-hydroxy-23-O-methylwalsuranolide, yunnanolide A (I), yunnanol A, 11β-hydroxyisowalsuranolide (II), 11β-hydroxy-1,2-dihydroisowalsuranolide, 1α,11β-dihydroxy-1,2-dihydroisowalsuranolide, 11β-hydroxy-1α-methoxy-1,2-dihydroisowalsuranolide, and yunnanolide B, together with a new cycloartane triterpenoid, (24S*,25R*)-cycloartane-3β,24,25,26-tetrol, were isolated from the leaves and twigs of W. yunnanensis. Their structures were elucidated on the basis of spectroscopic anal. and by comparison with literature data. I and II exhibited potent cytotoxicity against 5 human tumor cell lines with IC50 values in the range 2.2-4.2 μM. [on SciFinder(R)]

Animal cell line (SMMC-7721; antitumor activity of limonoids from leaves and twigs of Walsura yunnanensis); Antitumor agents; Human; Human cell line A549; Human cell line BEAS-2B; Human cell line HL-60; Human cell line MCF-7; Human cell line SW480 (antitumor activity of limonoids from leaves and twigs of Walsura yunnanensis)

University of Chinese Academy of Sciences; GUIZHOU MEDICAL UNIVERSITY