玄红专,女,博士,教授,山东省现代农业产业技术体系蜂产业创新团队蜂产品加工与质量控制岗位专家。主要从事蜂产品质量控制、蜂胶药理学活性研究。先后主持国家自然科学基金“蜂胶影响细菌内毒素诱导的血管内皮细胞自噬的分子机制研究”、“基于抗炎活性成分群的中国“杨树型”蜂胶质量评价体系研究“2项,山东省自然科学基金”蜂胶对脂多糖诱导的血管内皮细胞TLR4信号转导通路的影响“1项,山东省高等学校科技计划项目1项,参与国家自然科学基金、山东省自然科学基金等多项。研究工作集中在蜂产品质量控制、蜂胶的化学成分、生物学活性、药理作用等方面。在蜂胶方面做了大量的研究工作,积累了丰富的经验。硕士、博士学习期间曾分获浙江大学“三好研究生”称号。发表论文70余篇,其中SCI收录16篇。
科研成果
[1] Yuan W#, Chang H#, Liu X, Wang S, Liu H, Xuan H*. Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3K/Akt/mTOR-Mediated Nrf2/HO-1 Pathway. Evid Based Complement Alternat Med. 2019 Jul 7;2019:5789574.
[2] Hongzhuan Xuan*, Wenwen Yuan, Huasong Chang, Minmin Liu, Fuliang Hub*.Anti-inflammatory effects of Chinese propolis during lipopolysaccaride-stimulated human umbilical vein endothelial cells by suppressing autophagy and MAPK/NF-κB signaling pathway. Inflammopharmacology, 2019, 27:561-571.
[3] Huasong Chang, Wenwen Yuan, Haizhu Wu, Xusheng Yin, Hongzhuan Xuan*. Bioactive components and mechanisms of Chinese poplar propolis alleviates oxidized low-density lipoprotein-induced endothelial cells injury. BMC Complem Altern M, 2018, 18:142.
[4] Huasong Chang, Yuehua Wang, Xusheng Yin, Xinying Liu, Hongzhuan Xuan*. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. BMC Complementary and Alternative Medicine, 2017, 17:471.
[5] Hongzhuan Xuan, Yuehua Wang, Aifeng Li, Chongluo Fu , Yuanjun Wang , Wenjun Peng. Bioactive components of Chinese propolis water extract on antitumor activity and quality control. Evidence-Based Complementary and Alternative Medicine (eCAM), 2016, 2016: 9641965.
[6] Hongzhuan Xuan#, Junhong Zhang#, Yuehua Wang, Chongluo Fu, Wei Zhang. Anti-tumor activity evaluation of novel chrysin-organotin compound in MCF-7 cells. Bioorganic & Medicinal Chemistry Letters, 2016, 26(2):570-574.
[7] Hongzhuan Xuan, Zhen Li, Jiying Wang, Kai Wang, Chongluo Fu, Jianlong Yuan, Fuliang Hu. Propolis reduces phosphatidylcholine-specific phospholipase C activity and increasing annexin a7 level in oxidized LDL-stimulated human umbilical vein endothelial cells. Evidence-Based Complementary and Alternative Medicine (eCAM), 2014, 2014: 465383.
[8] Hongzhuan Xuan#, Zhen Li#, Haiyue Yan, Qing Sang, Kai Wang, Qingtao He, Yuanjun Wang, Fuliang Hu. Antitumor activity of Chinese propolis in human breast cancer MCF-7 and MDA-MB-231 cells. Evidence-Based Complementary and Alternative Medicine (eCAM), 2014, 2014: 280120.
[9] Hongzhuan Xuan, Ruiliang Zhu, Yajing Li, Fuliang Hu. Inhibitory effect of Chinese propolis on phosphatidylcholine -specific phospholipase C activity in vascular endothelial cells. Evidence-Based Complementary and Alternative Medicine (eCAM), 2011, 2011: 985278.
[10] Hongzhuan Xuan, Jing Zhao, Junying Miao, Yajing Li, Yafang Chu, Fuliang Hu. Effect of Brazilian propolis on human umbilical vein endothelial cell apoptosis. Food and chemical toxicology, 2011, 49(1): 78-85.
教育经历
-
浙江大学
特种经济动物饲养, 博士研究生, 2008-08至2011-06
-
浙江大学
特种经济动物饲养, 研究生, 2000-09至2003-07
-
山东农业大学
畜牧, 本科, 1996-09至2000-07