Our research utilizes molecular and cell biology technologies to understand the etiology and pathogenesis of Parkinson's Disease (PD), and develop potential treatment alternatives for PD in cellular, mice and rats models. There are some areas of focus: 1) identify enviomental risk factors for PD based on case-control studies via designed questionnaire for PD patients;  2) identify genetic risk factors for central Chinese PD population; 3) explore the pathogenesis of PD, such as GAPDH overexpression and aggragation; 4) develop neuroprotective medications based on risk factors and potential pathogenesis; 5) use the olfactory function assessment and functional magnetic resonance (DTI, MRS and SWI) to early diagnose PD.