Research Activities: 1. My research is about the mechanism of Cardiac Allograft Vasculopathy (CAV) and preventive strategy. CAV is a main obstacle on long-survival after heart transplantation. Up to now, the reason is unknown and chronic immune rejection probably is the main reason. My research is about chronic immune rejection. At first, rat model of heterotopic heart transplantation was developed by using microsurgical technique and CAV was detected by immunohitochemical technique and in situ hybridization technique. Cardiac allograft vasculopathy occurs in the grope of injecting subcutaneously low dosage CsA. I study the effect of expression of iNOSmRNA on CAV and the effect of cytokines on CAV such as PGEF, TGF on CAV. I transfer iNOS gene in order to prevent CAV after heart transplantation. 2. Heat shock protein is a group of proteins that its function is relative to immune rejection after heart transplantation. My research is major in the relationship between HSP70 function and immune rejection after transplantation. Clinic Activities: Attending operation including: Congenital heart disease: auricular septal defect, ventricular septal defect, tetralogy of Fallot, three auricular heart and so on; Rheumatic heart disease: mitral valve disease, aortic valve disease, combined valve disease; Coronary heart disease; Ruptured sinus of valsalva and so on.