蒲兴祥,湖南邵阳人,1978年10月出生。湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院,副主任医师,中南大学硕士研究生导师。除了对肺癌等胸部肿瘤的诊断和治疗有较前沿的研究外,对大肠癌、淋巴瘤等诊断和治疗也有较深的造诣,在肿瘤个体化治疗、免疫靶向治疗也有很好的经验。
联系方式
地址:湖南省长沙市岳麓区桐梓坡路283号,湖南省肿瘤医院胸部内二科 邮编:421001
手机:15874180022
Email:pxx_1354@163.com
教育经历(按时间倒排序):
2016/8 - 2017/11, 美国MDAnderson癌症中心,访问学者
2007/9 - 2010/7, 中山大学,肿瘤学,博士,
2002/9 - 2005/7, 中山大学,肿瘤学,硕士,
1997/9 - 2002/7, 南华大学,临床医学,学士,
学术兼职:
1.中国南方肿瘤临床研究协会(CSWOG)青年委员会常委,
2.中国中西医结合学会时间生物医学专业委员会委员,
3.CSCO黑色素瘤青年委员会委员,
4.湖南省抗癌协会肿瘤临床化疗专业委员会委员兼秘书,
5.湖南省医学会化疗专业委员会青年委员,
6.湖南省免疫学会青年委员会,
7.湖南省健康服务协会肿瘤防治分会常务理事兼秘书,
8.湖南省抗癌协会血液-淋巴瘤专业委员会委员,
9.中国康复技术转化及发展促进会精准医学与肿瘤康复专业委员会生物靶向治疗学组委员,
10.湖南省抗癌协会临床肿瘤协作专业委员会委员,
11.湖南省医学会肿瘤学专业委员会胸部肿瘤内科学组秘书,
12.美国临床肿瘤协会(ASCO)会员。
12.Oncotarget、Journal of Cancer Research Updates(SCI)杂志审稿专家,参编《恶性淋巴瘤诊断治疗学》
主持或参加科研项目(按时间倒序排序):
1.2016年姊妹医院联合基金(Sister Institution Network Fund, SINF):Novel STAT3/RNA Polymerase II inhibitor and its predictive biomarker for lung cancer therapy、 2017/6-2019/6、10万美元、 在研、 主持
2.2016年度省科技计划项目(省重点研发计划、创新平台与人才计划)2016JC2066 肺癌患者基因多态性对顺铂群体药代动力学参数及疗效的影响 2016/1-2019/12、10万、第三负责人
3. 湖南省自然科学基金课题,2015JJ6066、miRNA-221调控p53相关蛋白在结直肠癌中的临床意义、生物学功能及机制研究、2015/1--2017/12、3万元、已结题、主持
4. 湖南省卫生厅课题,B2012-095、miR-221在结直肠癌中的临床意义、生物学功能研究、2013/1-2015/12、2万元、已结题、主持
5. 湖南省肿瘤医院青年基金课题,放化疗联合抗EB病毒治疗鼻腔NK/T细胞淋巴瘤的临床研究、2012/01--2014/12、2万元、已结题、主持
文章发表:共已发表论文20篇(第一作者、通讯作者7篇:SCI 5篇)
1.miR-221 inhibits autophagy and targets TP53INP1 in colorectal cancer cells.
Liao D, Li T, Ye C, Zeng L, Li H, Pu X, Ding C, He Z, Huang GL.Exp Ther Med. 2018 Feb;15(2):1712-1717.
2.Association of microRNA-423 rs6505162 C>A polymorphism with susceptibility and metastasis of colorectal carcinoma.
Jia W, Zeng L, Luo S, Bai F, Zhong R, Wu L, Huang GL, Pu X.
Medicine (Baltimore). 2018 Feb;97(6):e9846.
3.Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Yan X, Wang L, Zhang R, Pu X, Wu S, Yu L, Meraz IM, Zhang X, Wang JF, Gibbons DL, Mehran RJ, Swisher SG, Roth JA, Fang B. Oncoimmunology. 2017 Oct 31;7(1):e1376156.
4.TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC). Cao X, Zhao Y, Wang J, Dai B, Gentile E, Lin J, Pu X, Ji L, Wu S, Meraz I, Majidi M, Roth JA. Oncotarget. 2017 Nov 21;8(64):107621-107629.
5.Variants with a low allele frequency detected in genomic DNA affect the accuracy of mutation detection in cell-free DNA by next-generation sequencing.
Wang JF, Pu X, Zhang X, Chen K, Xi Y, Wang J, Mao X, Zhang J, Heymach JV, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Meng QH, Shaw KR, Eterovic AK, Fang B. Cancer. 2018 Mar 1;124(5):1061-1069.
6.miR-96 induces cisplatin chemoresistance in non-small cell lung cancer cells by downregulating SAMD9. Lin Wu, XingXiang PU, QianZhi Wang, Jun Cao, Fang Xu, Li Xu, Kang Li.Oncol Lett. 2016 ; 11(2): 945–952.
7.Pharmacogenomics research: a potential strategy for drug development. Wen JG, Wu L, Pu XX, He FZ, Liu MZ, Zhou HH, Zhang WPharmazie. 2015 ;70(7):437-45
8.Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression. Pu XX, Huang GL, Guo HQ, Guo CC, Li H, Ye S, Ling S, Jiang L, Tian Y, Lin TY. J Gastroenterol Hepatol. 2010 Oct;25(10):1674-80
9.Comparison of KRAS/BRAF mutations between primary tumors and serum in colorectal cancer: Biological and clinical implications. Pu XX, Pan Z, Huang Y, Tian Y, Guo H, Wu L, He X, Chen X, Zhang S, Lin T. Oncol Lett. 2013 Jan;5(1):249-254
10.Association study between miR-149 gene polymorphism and nasopharyngeal carcinoma.Huang GL, Lu Y, Pu XX(co-first author), He YX, Chen ML, Li YZ, Tang SY, Che H, He Z. Biomed Rep. 2013 Jul;1(4):599-603.
11.Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population.Huang GL, Chen ML, Li YZ, Lu Y, Pu XX, He YX, Tang SY, Che H, Zou Y, Ding C, He Z .J Hum Genet. 2014 Mar;59(3):141-4
12.Cyclin D1 G870A Polymorphism and Risk of Nasopharyngeal Carcinoma: A Case-Control Study and Meta-Analysis. Liao D, Wu Y, Pu X, Chen H, Luo S, Li B, Ding C, Huang GL, He Z.PLoS One. 2014 Nov 19;9(11)
13.Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma. Lu Y, Huang GL,Pu XX(co-first author), He YX, Li BB, Liu XY, Dong Z, He Z. Mol Biol Rep. 2013 May;40(5):3777-82.
14.Diagnostic and prognostic value of circulating miR-221 for extranodal natural killer/T-cell lymphoma..Guo HQ, Huang GL, Guo CC, Pu XX, Lin TY.Dis Markers. 2010;29(5):251-8.
15.Comparison of entecavir and lamivudine in preventing hepatitis B reactivation in lymphoma patients during chemotherapy.Li HR, Huang JJ, Guo HQ, Zhang X, Xie Y, Zhu HL, Zhai LZ, Pu XX, Huang Y, Guo CC, Lin TY.J Viral Hepat. 2011 ;18(12):877-83.
16.5-Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells.Deng YH, Pu XX, Huang MJ, Xiao J, Zhou JM, Lin TY, Lin EH.Chin J Cancer. 2010 Sep;29(9):810-5.
17.The role of Skp2 in extranodal NK/T-cell lymphoma. Guo HQ, Pu XX, Guo CC, Rao HL, Li HR, Lin TY. Chin J Cancer. 2010 ;29(5):567-71.
18.Effect of KRAS mutation on efficacy of Cetuximab combined with chemotherapy in advanced colorectal cancer patients. Pu XX, Deng YH, Xu F, Xiao J, Guo HQ, Huang H, Tian Y, He YJ, Lin TY.Zhonghua Wei Chang Wai Ke Za Zhi. 2009 Nov;12(6):594-7. Chinese.
19.In vitro inhibitory effect of dibenzoxanthene CY-B12 on proliferation of tumor cell lines and its possible mechanisms. Pu XX, Jiang GF, Chen Y, Xu ZL, Xian LJ.Ai Zheng. 2005 Dec;24(12):1442-7. Chinese.
20.Association of PIN1 promoter polymorphisms with colorectal carcinoma risk and clinicopathological parameters.Liuyan Zeng, Guoliang Huang, Shengqun Luo, Xingxiang Pu, Dan Liao, Huahui Li, Tong Li, Yingqin Li, Wenrui Jia, Zhiwei He. Int J Clin Exp Pathol 2016;9(9):9619-9624