苑玉和，研究员，博士生导师 主要研究方向：抗帕金森病创新药物研制及作用机制的研究。具体研究内容：利用分子生物学技术，在分子、细胞和动物水平构建帕金森病研究模型及平台，在此基础上研究帕金森病发病机制及创新药物。近五年来负责课题共8项，其中国家级项目5项，北京市重点项目1项。近5年发表SCI收录文章30余篇，申请专利5项，部分成果如下： 发表文章 第一作者和通讯作者 1. Shao QH, Yan WF, Zhang Z, Ma KL, Peng SY, Cao YL, Yuan YH*, Chen NH*. Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells. Neuropharmacology. 2018, 99:115-123 (IF=5.012) 2. Wen L# ,Zhang QS, Heng Y, Chen Y, Wang S, Yuan YH*, Chen NH*. NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model. Toxicol Lett. 2018, 5(288):1-8. (IF=3.858) 3. Shao QH, Zhang XL, Chen Y, Zhu CG, Shi JG, Yuan YH*, Chen NH*. Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways. Mol Immunol. 2018 May 12;99:115-123 (IF=3.236 ) 4. Zhang QS, Heng Y, Chen Y, Luo P, Wen L, Zhang Z, Yuan YH*, Chen NH*. A novel bibenzyl compound, 20C, protected mice from MPTP/p toxicity by regulating alpha-synuclein related inflammatory response.J Pharmacol Exp Ther. 2017 Nov;363(2):284-292. doi: 10.1124/jpet.117.244020. Epub 2017 Sep 14. (IF: 3.867). 5. Zhang Q, Yang H, Mou Z, Huang JY, Yuan YH*, Chen NH. * Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease[J]. Acta Pharmacologica Sinica, 2017 Oct;38(10):1317-1328. doi: 10.1038/aps.2017.49. (IF: 3.223). 6. Shao QH, Zhang XL, Yang PF, Yuan YH*, Chen NH*.Amyloidogenic proteins associated with neurodegenerative diseases activate the NLRP3 inflammasome.Int Immunopharmacol. 2017 Aug;49:155-160. doi: 10.1016/j.intimp.2017.05.027. Epub 2017 Jun 5. (IF: 2.956) Review 7. Qiu-Shuang Zhanga, Yang Henga, Yu-He Yuan*, Nai-Hong Chen*. Pathological α-Synuclein Exacerbates the Progression of Parkinson’s Disease through Microglial Activation. Toxicol Lett 2017, 265(4) :30-37. (IF: 3.5)(Review) 8. Yang Heng, Qiu-Shuang Zhang, Zheng Mu, Jin-Feng Hu, Yu-He Yuan*, Nai-Hong Chen* Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra, Toxicol Lett, 2016; 243:7-21 9. Yuan YH, Yan WF, Sun JD, Huang JY, Mu Z, Chen NH.The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway. Toxicol Lett, 2015; 233: 163-171. 10. Yuan YH, Sun JD, Wu MM, Hu JF, Peng SY, Chen NH.Rotenone could activate microglia through NFκB associated pathway. Neurochem Res. 2013;38:1553-60 11. Yan WF, Shao QH, Zhang DM, Yuan YH*, Chen NH*. The molecular mechanism of polygalasaponin F-mediated decreases in TNF α: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res, 2015; 17: 662-670. 12. Wu MM, Yuan YH, Chen J, Li CJ, Zhang DM, Chen NH. Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. J Asian Nat Prod Res 2014; 16:59-69. (共同第一） 13. Wei W, Yuan YH, Gao YN, Yan WF, Li CJ, Zhang DM, Chen NH. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-kappaB pathway regulation. J Asian Nat Prod Res 2014; 16:865-875.(共同第一） 14. Yuan Y, Sun J, Zhao M, Hu J, Wang X, Du G, Chen NH. Overexpression of alpha-synuclein down-regulates BDNF expression. Cell Mol Neurobiol. 2010;30:939-46. 15. 闫文芬, 衡洋，邵千航，陈乃宏，苑玉和*. 建立以α-突触核蛋白损伤为靶点的细胞筛选模型. 中国药理学通报, 2015; 31: 586 -590. 16. 闫文芬, 陈乃宏，苑玉和*.α-突触核蛋白与Cu2+ 相互作用的研究进展.中国药理学通报, 2015; 31: 7-10. 17. 苑玉和，吴苗苗，刘岩，胡金凤，王宏旭，陈乃宏*，建立NF-B核转位的转基因细胞模型，药理学通报，2012;28: 726-728 署名文章 1. Yan JQ, Yuan YH, Gao YN, Huang JY, Ma KL, Gao Y, Zhang WQ, Guo XF, Chen NH.Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.Mol Neurobiol. 2014;50:685-701 2. Ma KL, Song LK, Yuan YH, Zhang Y, Han N, Gao K, Chen NH. The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle.Neuropharmacology. 2014;82:132-42 3. Ma KL, Song LK, Yuan YH, Zhang Y, Yang JL, Zhu P, Chen NH.α-Synuclein is prone to interaction with the GC-box-like sequence in vitro. Cell Mol Neurobiol. 2014;34:603-9 4. Song XY, Hu JF, Sun MN, Li ZP, Zhu ZX, Song LK, Yuan YH, Liu G, Chen NH IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia.Brain Res Bull. 2014;106:30-8 5. Song LK, Ma KL, Yuan YH, Mu Z, Song XY, Niu F, Han N, Chen NH*. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PLoS One 2015; 10: e0131281 6. Liu Y, Sun JD, Song LK, Li J, Chu SF, Yuan YH, Chen NH*. Environment-contact administration of rotenone: A new rodent model of Parkinson’s disease. Behav Brain Res, 2015; 294: 149-161. 7. Song XY, Hu JF, Chu SF, Zhang Z, Xu S, Yuan YH, Han N, Liu Y, Niu F, He X, Chen NH.Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats.,Eur J Pharmacol. 2013; 710:29-38. 8. Ma KL, Song LK, Long WA, Yuan YH, Zhang Y, Song XY, Niu F, Han N, Chen NH.Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells. Brain Res Bull. 2013;90:127- 9. Sun JD, Liu Y, Yuan YH, Li J, Chen NH. Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats.Neuropsychopharmacology. 2012;37:1305-20 10. Ma KL, Yuan YH, Song LK, Han N, Chen NH.Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone. Neurosci Lett. 2011;491:148-52. 负责的在研项目 1. 国家自然基金面上项目:人参皂苷Rg1通过α-突触核蛋白介导的炎症通路干预帕金森病的机制研究（81573640），2016/01-2019/12 2. 北京市自然基金重点项目：以帕金森病的朊蛋白样聚集为靶点筛选新结构化合物和创新药物(7161011), 2016/01-2019/12 3. 国家自然基金面上项目：项目名称：基于脑-肠轴研究天麻新型四聚苄化合物对帕金森病模型保护作用的机制（81773925），2018/01-2021/12