Our research utilizes molecular and cell biology technologies to understand the etiology and pathogenesis of Parkinson's Disease (PD) and dystonia, and develop potential treatment alternatives for PD and dytonia  in cellular, Caenorhabditis elegans, mice and rats models. There are eight areas of focus: 1) identify enviomental risk factors for PD based on case-control studies via designed questionnaire for PD patients;  2) identify genetic risk factors for central Chinese PD population and use Caenorhabditis elegans and animal models to confirm the risk factors; 3) explore the pathogenesis of PD, such as GAPDH overexpression and aggragation, neuronal cell cycle re-entry and autophagy block; 4) develop neuroprotective medications based on risk factors and potential pathogenesis; 5) devise novel genetic approaches to helping understand environment-gene interaction; 6) transplant stem cells to treat PD animal models; 7) use the olfactory function assessment and functional magnetic resonance (DTI, MRS and SWI) to early diagnose PD or dystonia patients; 8) translational medicine for clinical PD patients.