Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.

Chen, Danian; Livne-bar, Izhar; Vanderluit, Jackie L; Slack, Ruth S; Agochiya, Mahima; Bremner, Rod

Cancer Cell, 2004, 5(6): 539-551.

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E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.

Chong, Jean-Leon; Wenzel, Pamela L; Saenz-Robles, M Teresa; Nair, Vivek; Ferrey, Antoney; Hagan, John P; Gomez, Yorman M; Sharma, Nidhi; Chen, Hui-Zi; Ouseph, Madhu; Wang, Shu-Huei; Trikha, Prashant; Culp, Brian; Mezache, Louise; Winton, Douglas J; Sansom, Owen J; Chen, Danian; Bremner, Rod; Cantalupo, Paul G; Robinson, Michael L; Pipas, James M; Leone, Gustavo

Nature, 2009, 462(7275): 930-934.

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Division and apoptosis of E2f-deficient retinal progenitors.

Chen, Danian; Pacal, Marek; Wenzel, Pamela; Knoepfler, Paul S; Leone, Gustavo; Bremner, Rod

Nature, 2009, 462(7275): 925-929.

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Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a.

Chen, Danian; Opavsky, Rene; Pacal, Marek; Tanimoto, Naoyuki; Wenzel, Pamela; Seeliger, Mathias W; Leone, Gustavo; Bremner, Rod

PLoS Biology, 2007, 5(7).

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Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.

McClellan, Kelly A; Ruzhynsky, Vladimir A; Douda, David N; Vanderluit, Jacqueline L; Ferguson, Kerry L; Chen, Danian; Bremner, Rod; Park, David S; Leone, Gustavo; Slack, Ruth S

Molecular and Cellular Biology, 2007, 27(13): 4825-4843.

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Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina.

Livne-Bar, Izzy; Pacal, Marek; Cheung, Melissa C; Hankin, Mark; Trogadis, Judy; Chen, Danian; Dorval, Kimberley M; Bremner, Rod

Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(13): 4988-4993.

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The RB protein family in retinal development and retinoblastoma: new insights from new mouse models.

Bremner, Rod^*; Chen, Danian; Pacal, Marek; Livne-Bar, Izhar; Agochiya, Mahima

Developmental Neuroscience, 2004, 26(5-6): 417-434.

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Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.

Sangwan, M; McCurdy, S R; Livne-Bar, I; Ahmad, M; Wrana, J L; Chen, D^*; Bremner, R^*

Oncogene, 2012, 31(48): 5019-5028.

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Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.

Zencak, Dusan; #Schouwey, Karine; #Chen, Danian; Ekstrom, Per; Tanger, Ellen; Bremner, Rod; van Lohuizen, Maarten; Arsenijevic, Yvan^*

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(7).

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E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3.

Chen, D; Chen, Y; Forrest, D; Bremner, R^*

Cell Death and Differentiation, 2013, 20(7): 931-940.

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