Kun Ping Lu (goes by Ping) originally discovered a number of new genes that bear his name, including Pin1-3 and PinX1-4, and a novel signaling mechanism called “post-phosphorylation conformational regulation”. Ping demonstrated that this new mechanism has profound impact not only on basic science and disease development, but also may lead to new diagnostic and therapeutic procedures on diseases as diverse as cancer and Alzheimer’s disease. Therefore, Ping has created a new science field that is widely studied in hundreds of laboratories around the world. Therefore, Ping has not only directed a top-rated academic research program at Harvard University, but has extensive experiences in drug discovery and management in the pharmaceutical setting. The major discoveries are summarized in the following seven areas. 1) Pin1-catalyzed prolyl isomerization is a novel signaling mechanism. 2) Pin1 is a novel catalyst for tumorigenesis and a new anticancer target. 3) Pin1 is a pivotal enzyme helping prevent Alzheimer disease. 4) Pin1 is an essential novel regulator of telomere maintenance and aging. 5) Pin1 is an essential conformational switch in innate and adaptive immunity. 6) PinX1 is a telomerase inhibitor and major tumor suppressor. 7) Development of Pin-based novel diagnotic and therapeutic procedures.