Linfoma T/NK extraganglionar tipo nasal: caso cl赤nico y revisi車n de la literatura

作者：Khosravi Shahi; P; Diaz Muoz de la Espada; V M

来源：Anales de Medicina Interna, 2005.

DOI：10.4321/S0212-71992005001200010

• t/nk lymphoma extranodal
• cd56
• ccd3
• ebv
• nasal type.

extranodal t/nk-cell lymphoma, nasal type: a case report and review of the literature. extranodal nk/t-cell lymphoma, nasal type, is an extranodal lymphoma, usually with an nk-cell phenotype and ebv possitive, with a broad morphologic spectrum, frequent necrosis and angioinvasion, and most commonly presenting in the midfacial region, but also in other extranodal sites. we present the case of a 42-years old-man with a intranasal mass, left cervical adenopathies and indolent thrombocytosis. the biopsy of the nasal mass showed a diffuse infiltrate of medium-sized lymphoid cells, with slightly irregular nuclei and moderate polymorphous. the immunophenotype of tumor cells was cd45+, ccd3+, granzyme b+, cd56+, cd20-,cd4-,cd8-, lmp1(ebv)-. the diagnosis of the case was extranodal t/nk-cell lymphoma, nasal type. there was not disseminated disease in the extent studies. with the diagnosis of localized extranodal t/nk-cell lymphoma and reactive thrombocytosis, the patient was treated with chemotherapy and sequential radiotherapy, followed by bone marrow transplantation.