Bronquiolite associada 角 exposiˋˋo a aroma artificial de manteiga em trabalhadores de uma f芍brica de biscoitos no Brasil

作者：Cavalcanti; Zaida do Rego; Albuquerque Filho; Alfredo Pereira Leite de; Pereira; Carlos Alberto de Castro; Coletta; Ester Nei Aparecida Martins

来源：Jornal Brasileiro de Pneumologia, 2012.

DOI：10.1590/S1806-37132012000300016

• diacetyl
• flavoring agents
• bronchiolitis.

objective: to report the cases of four patients with bronchiolitis caused by exposure to artificial butter flavoring at a cookie factory in brazil. methods: we described the clinical, tomographic, and spirometric findings in the four patients, as well as the lung biopsy findings in one of the patients. results: all four patients were young male nonsmokers and developed persistent airflow obstruction (reduced fev1/fvc ratio and fev1 at 25-44% of predicted) after 1-3 years of exposure to diacetyl, without the use of personal protective equipment, at a cookie factory. the hrct findings were indicative of bronchiolitis. in one patient, the surgical lung biopsy revealed bronchiolitis obliterans accompanied by giant cells. conclusions: bronchiolitis resulting from exposure to artificial flavoring agents should be included in the differential diagnosis of airflow obstruction in workers in brazil.