摘要

目的探讨老年不同糖耐量人群血清网膜素-1(omentin-1)水平与年龄、腰臀比(WHR)、体重指数(BMI)、血糖、胰岛素、血脂及胰岛素敏感性的关系。方法收集初诊老年2型糖尿病(DM)患者及老年糖耐量受损(IGT)患者,设健康老年患者为正常对照组(NGT),酶联免疫法测定了以上三组人群空腹和糖负荷后2h血清网膜素-1水平,分析血清网膜素-1与年龄、血压、BMI、WHR、胰岛素抵抗指数(HOMA-IR)、血脂、血糖、胰岛素水平等的关系。结果与NGT组相比,DM组空腹和糖负荷后2h血清网膜素-1水平明显降低,IGT组网膜素-1水平介于DM组和对照组之间;肥胖组血清网膜素水平明显低于非肥胖组;相关性研究显示,血清网膜素-1水平与年龄、WHR、糖负荷后2h血糖(2hPG)、HbA1C、HOMA-IR均呈负相关;多元线性逐步回归分析表明WHR、糖负荷后2h血糖(2hPG)、HbA1c分别是影响血清网膜素-1水平的独立相关因素。结论血清网膜素-1水平与老年人糖代谢状态有关,并可能在老年肥胖症及2型糖尿病的发生和发展中具有一定的作用。

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2

被引

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Wang Haijun*
3rd International Conference on Information Technology and Career Education (ICITCE), 2015-12-24 to 2015-12-25.
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