2-氨基-5-氟吡啶的合成

作者：李斌; 黄钢

来源：中国医药工业杂志, 2006, (12): 806-807.

DOI：10.3969/j.issn.1001-8255.2006.12.006

• 2-amino-5-fluoropyridine
• intermediate
• synthesis 2-amino-5-fluoropyridine
• intermediate
• synthesis

2-Amino-5-fluoropyridine was synthesized from 2-acetamido-5-aminopyridine by diazotization with NaNO2/HBF4 to obtain 2-acetamido-5-pyridinediazonium tetrafluoroborate, which was subjected to solventless thermolysis followed by hydrolysis in 66% overall yield.

• 单位
  上海交通大学; 上海交通大学医学院附属仁济医院