Fragment‐based drug discovery as alternative strategy to the drug development for neglected diseases

作者：Juliana da Fonseca Rezende e Mello; Renan Augusto Gomes; Drielli Gomes Vital‐Fujii; Glaucio Monteiro Ferreira; Gustavo Henrique Goulart Trossini

来源：Chemical Biology & Drug Design, 2017, 90(6): 1067-1078.

DOI：10.1111/cbdd.13030

• drug design
• FBDD
• fragment
• hit
• neglected diseases
• screening

Neglected diseases ( ND s) affect large populations and almost whole continents, representing 12% of the global health burden. In contrast, the treatment available today is limited and sometimes ineffective. Under this scenery, the Fragment‐Based Drug Discovery emerged as one of the most promising a...