Infecci車n aguda por el VHC

作者：Martinez Echeverria; A; Rodriguez Gutierrez; C; Elizalde; I; Zozaya; J M

来源：Anales del Sistema Sanitario de Navarra, 2004.

DOI：10.4321/S1137-66272004000400008

• acute hepatitis
• clinical manifestations
• diagnosis
• treatment
• interferon.

acute hepatitis c virus infection produces clinical and biochemical features that is non-specific and indistinguishable from those caused by other hepatotropic viruses. the specific diagnosis of acute hepatitis c virus infection is based on the detection of serum rna-hcv through a technique of pcr whose result will be positive after 1-2 weeks of the initial contact with the virus. the anti-bodies against hcv are detected later (after 7-8 weeks on average), and are not useful, as an isolated determination, in distinguishing acute infection from chronic infection or in clearing the virus (spontaneous or following treatment). fifty-five to eighty-five percent of patients with acute hcv infection do not clear the virus and develop a chronic infection with risk of evolution to cirrhosis and of developing hepatocellular carcinoma. for this reason, the present tendency is to treat with interferon all those patients in whom rna-hcv remains positive after 3-4 months following diagnosis of acute infection.