Rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with1,4,2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective C-H bond activation

作者：Jie Ren; Yanzhen Huang; Chao Pi; Xiuling Cui^*; Yangjie Wu^*

来源：Chinese Chemical Letters, 2021, 32(08): 2592-2596.

A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones.This reaction features excellent regioselectivity,broad substrate scope and high step economy,which would provide the refe rence for the construction of the fused 4-aminoquinazolines with biologically and pharmacologically active compounds.

• 单位
  郑州大学