科研之友
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摘要
context: chronic feet and leg ulcers affect about 2.7% of the brazilian population, 10% of diabetic patients. the condition represents the second most frequent cause of absence from work in brazil. this shows the need for a product that promotes healing of these wounds at a low cost. objective: to evaluate the effects of metronidazole on ulcer healing by second intention. methods: eighty male rats divided into two groups of 40 had a wound made on their dorsum. the control group was treated with a 0.9% nacl solution and the experimental group was treated with 4% metronidazole. on the third, seventh, 14th and 21st days, the healing process was assessed through macroscopical, histological and immunohistochemical parameters. results: collagen concentration was higher in wounds in the experimental group in all samples. concentration of type i collagen was also significant on the 7th (p = 0.020) and 21st (p = 0.016) days. concentration of type iii collagen was similar in both groups in the initial phase, but it was higher in the experimental group on the 21st day (p = 0.005). angiogenesis, assessed with anti-cd34, revealed a larger number of vessels in the experimental group, with a significant difference on the third (p %26lt; 0.001) and 14th (p = 0.003) days. conclusion: metronidazole contributes to healing wounds by second intention and stimulates collagen production and angiogenesis.
