Antimicrobial Resistance of Nosocomial Strain of Acinetobacter baumannii in Children＊s Medical Center of Tehran: A 6-Year Prospective Study

作者：Setareh Soroush; Mohammad Taghi Haghi Ashtiani; Morovat Taheri Kalani; Mohammad Emaneini

来源：Acta Medica Iranica, 2010.

• Drug resistance
• multiple
• Acinetobacter baumannii
• cross infection

%26quot;nThere are increasing reports of emergence of multiple drug resistant (MDR) Acinetobacter spp in the world; however there are a few reports in our country. 145 A. baumannii isolates from distinct wards and Children%26apos;s Medical Center (CMC) in Tehran were studied in order to find the profile of antibiotic resistance among them. 40.6% (59/145) of A. baumannii isolates were identified as MDR. Overall susceptibility rates to cotrimoxazole, chloramphenicole and ciprofloxacin were 23.4%, 16.9% and 20.1%, respectively. Frequency susceptibility rates to amikacin, kanamycin, gentamycin and tobramycin decreased gradually from 81.2%, 50%, 50% and 62.5% in 2002 to 25%, 15.6%, 28.1% and 25% in 2007 respectively. Overall susceptibility rates to cephalosporines cephalotin, ceftazidime, cefteriaxon, ceftizoxime and cefixime were 9.3%, 14.7%, 16.2%, 15.9% and 18%, respectively. Susceptibility to carbapenems was assessed only in 2007. The susceptibility rates of Imipenem and meropenem were shown to be 50% and 46.8%, respectively. Our data indicates that MDR A. baumannii strains are spreading and carbapenem resistance is becoming more common in Iran. Our findings also highlight the importance of clinicians%26apos; access to updated susceptibility data regarding A. baumannii in developing countries such as Iran.