科研之友
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摘要
With the complementary and synergistic effects on anticancer function, the combined utilization of photothermal therapy and immunotherapy is one of the priority methods for eliminating solid tumor and metastatic tumor. However, the limitations of photothermal immunoagents currently in use bring drawbacks to their clinical application prospects. The development and optimization of this combined therapy have become a research hotspot in the field of cancer treatment. More and more attention has been paid to functional assemblies based on oligopeptide molecular design. Such assemblies can not only design the assembly structure through amino acid encoding, but also achieve excellent anti-tumor therapeutic performance through the introduction of bioactive peptides. In this feature article, we summarize the recent researches on oligopeptide-based assemblies for tumor photothermal immunotherapy in terms of the different roles of peptide molecules in the construction of assembly system. We first discuss the roles of oligopeptides participating in the assembly regulation of photothermal immune system, and then elaborate the mechanisms of oligopeptides in optimizing system stability, enhancing photothermal conversion efficiency, and inducing immune response in the assembly process. In addition, we also summarize the roles of different functional peptides in photothermal immunotherapy of cancer, and discuss the application prospect of oligopeptide assembly in cancer therapy.
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单位生化工程国家重点实验室; 中国科学院大学
