Silk Microneedle Patch Capable of On‐Demand Multidrug Delivery to the Brain for Glioblastoma Treatment (Adv. Mater. 1/2022)

作者：Wang Zijing; Yang Zhipeng; Jiang Jianjuan; Shi Zhifeng; Mao Ying; Qin Nan; Tao Tiger H.

来源：Advanced Materials, 2022, 34(1).

DOI：10.1002/ADMA.202270008

• drug delivery
• glioblastoma
• microneedle patches
• silk proteins

Tumor Therapy(#br)In article number 2106606, Nan Qin, Tiger H. Tao, and co‐workers report a heterogenous silk microneedle patch to spatiotemporally and sequentially deliver multiple therapeutic drugs for hemostasis, anti‐angiogenesis, and apoptosis of brain tumor cells. Drug release kinetics are well‐defined by tuning the crosslinking degree of the silk and applying a trigger of transcranial NIR‐light irradiation. This biodegradable patch has potential applications for the clinical treatment of intracranial tumors.

• 单位
  中国科学院大学; 复旦大学; 上海师范大学; 传感技术国家重点实验室