A New Prenylated Isoflavone from the Stems of Harrisonia perforata [牛筋果茎中一个新的异戊烯基异黄酮类化合物]

作者：Shen Z.; Li Y.; Zhao Y.; Deng Y.; Guo Y.; Wang Y.; Liu Y.; Fu Y.

来源：Chinese Journal of Organic Chemistry, 2023, 43(2): 771-776.

DOI：10.6023/cjoc202207005

• H. perforata
• Harrisonia
• prenylated isoflavone
• tumor cell growth inhibitory activities

A new prenylated isoflavone, harriperforine (1), as well as seven known analogues, was isolated and characterized from the stems of Harrisonia perforata. Their chemical structures were unambiguously elucidated based on spectroscopic analyses. All known compounds 2～8 were isolated from the genus Harrisonia for the first time. The growth inhibitory activities against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480) of compounds 1～8 were evaluated. As a result, compounds 1～8 displayed remarkable inhibitory activities with IC50 values ranging from (0.38±0.03) μmol/L to (31.68±0.21) μmol/L, which were comparable to those of cisplatin.

• 单位
  海南师范大学