纳米医学用于CRISPR-Cas9基因编辑技术治疗疾病（英文）

作者：马丽芳; 董彩虹; 余美华^*; 宋新然; 于永春^*; 陈雨^*

来源：Science Bulletin, 2022, 67(06): 572-576.

<正>In recent years,the clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9) technology that won the 2020 Nobel Prize in Chemistry has served as one of the most prominent and powerful tools in gene editing for biomedical research and the treatment of various diseases [1].Nevertheless,it remains a substantial challenge to effectively and safely deliver CRISPR-Cas9 molecules into target cells [2].Viral-based carriers have been broadly used in CRISPR-Cas9 delivery,but there are still some intrinsic flaws,such as low packing capacity,tumorigenesis,

• 单位
  复旦大学; 上海交通大学; 上海大学