Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity Alteraci車n de los Niveles de Excitabilidad Nodal por Efectos Inhibitorios Velocidad-Dependiente del Aceite Esencial de Citrus aurantium sobre las Propiedades E

作者：Vahid Khori; Mohsen Nayebpour; Azad Reza Mansourian; Ali Davarian

来源：International Journal of Morphology, 2010.

• Citrus aurantium
• Nodo AV aislado
• Arritmia
• Drogas herbales
• Citrus aurantium
• Isolated AV-node
• Arrhythmia
• Herbal drugs

Treatment of supraventricular arrhythmia includes a wide range of medical interventions. Herbal remedies are suitable alternatives to synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of Citrus aurantium L. (Rutaceae) in many instances. In the present study we used isolated perfused AV-node of rabbit as an experimental model to determine the effect of various concentrations of essential oil of C. aurantium (0.1-0.3 v/v) on the nodal conduction time and refractoriness of an isolated rabbit AV-nodal preparations. Selective stimulation protocols were used to independently quantify AV nodal recovery, facilitation and fatigue in 18 rabbits. Our results showed concentration-dependent and rate-independent suppressive effects of essence of C. aurantium on the Wenchebach cycle length (WBCL), AV Conduction Time (AVCT) and effective and functional refractory periods (ERP %26 FRP). Functional properties such as facilitation and fatigue were significantly increased by this plant. Citrus aurantium plays a protective role against the toxic effects of ouabaine by increasing AV nodal conduction time and refractoriness. The above results indicated differential effects of C. aurantium on slow and fast pathways, with a dominant role on fast pathways. This research has explained the protective role of C. aurantium on ouabaine toxicity. All results indicated the potential anti-arrhythmic effects of C. aurantium in treating supraventricular tachyarrhythmia. El tratamiento de la arritmia supraventricular incluye una amplia gama de intervenciones m谷dicas. Los remedios herbarios son alternativas adecuadas a las drogas sint谷ticas debido a su disponibilidad, con escasos efectos secundarios y bajo precio. Estudios farmacol車gicos y la literatura m谷dica tradicional se alan los efectos cardiovasculares de Citrus aurantium L. (Rutaceae) en muchos casos. En el presente estudio se usaron aislados perfundidos del nodo AV de conejo como modelo experimental para determinar el efecto de diferentes concentraciones de aceite esencial de C. aurantium (0,1-0,3 v/v) sobre en el tiempo de conducci車n nodal y refractariedad. Un protocolo de estimulaci車n selectiva se utiliz車 para cuantificar de forma independiente la recuperaci車n, la facilitaci車n y la fatiga del nodo AV en 18 conejos. Nuestros resultados muestran efectos supresores dependientes de la concentraci車n e independiente de la velocidad de la esencia de C. aurantium sobre la duraci車n del ciclo Wenchebach (WBCL), tiempo