Ruthenium-catalyzed synthesis of 1,3,5-triazin-2(1H)-ones and dihydro[1,3,5]triazino[1,2-a]benzimidazoles from alcohols and guanides

作者：Zeng, Ming; Xie, Zhong Pao; Cui, Dong-Mei^*; Zhang, Chen^*

来源：New Journal of Chemistry, 2018, 42(14): 11905-11907.

DOI：10.1039/c8nj02035c

• C-H
• BIOLOGICAL-ACTIVITY
• BORROWING HYDROGEN
• DERIVATIVES
• ALKYLATION
• DEHYDROGENATION
• DISCOVERY
• ACID
• RING

An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazinones from alcohols and guanylureas under mild conditions has been developed. The scope of both the alcohols and guanylureas in the reaction is demonstrated. This ruthenium-catalyzed ring-forming process can be successfully extended to 2-guanidinobenzimidazoles to afford substituted dihydro[1,3,5]triazino[1,2-a]benzimidazoles.

• 单位
  浙江大学; 浙江工业大学