科研之友
微信
新浪微博
Facebook
分享链接
摘要
objective: to analyze total lymphocyte count, total leukocyte count, hemoglobin levels, nutritional status, cd4+ t-lymphocyte count and viral load as markers of disease progression and/or death in hiv-infected children. methods: this retrospective cohort study assessed antiretroviral naˋve hiv-infected children who were asymptomatic or had mild and/or moderate symptoms. the events of interest were: progression to clinical category c (according to the classification of the centers for disease control and prevention - cdc, 1994) or death. values of total leukocyte count, total lymphocyte count, hemoglobin, weight-for-age z score, cd4+ t-lymphocyte count and plasma viral load obtained at admission were considered in the risk analysis of events of interest. the population was stratified into age groups: 12 to 36 to %26lt; 60 months. results: one hundred and twenty patients, admitted between 1997 and 2003, met the inclusion criteria for the present study. the total median of follow-up duration was 7.4 months (25-75% interquartile range = 3.8-21.1). in the multivariate analysis, only cd4+ t-lymphocytes count, according to the categories of the world health organization, and weight-for-age z score ≒ -2 were predictors of risk for disease progression in children older than 12 months. in children younger than 12 months, none of the variables was associated with risk of progression. conclusion: nutritional status is an important aspect in the assessment of risk of disease progression in hiv-infected children older than 12 months.
