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摘要
Objective To investigate the effect of emotional cues on prospective memory (PM) in obsessive-compulsive disorder (OCD) patients. Methods From December 2014 to November 2019, 157 patients with obsessive-compulsive disorder (OCD) and 119 healthy controls (HC) matched for age, gender and intelligence participated in the study. A laboratory event-based PM paradigm was used to assess the PM function. The PM Accuracy (PM acc) of prospective memory pictures with different emotional cues in the two groups was investigated by a mixed design of 2 (group: OCD group, HC group) ×3 (emotional cue attributes: positive, neutral, and negative). Correlation analysis was used to explore the relationship between PM acc and clinical variables in patients with OCD. Results Repeated measures ANOVA showed that the main effect of emotional cues was not significant (F=0.377, P>0.05), the difference between the two groups was significant (F=8.863, P<0.01, η2=0.030), and the PM acc of the OCD group was lower than HC. The interaction was significant (F=3.261, P<0.05, η2=0.012). Further simple effect analysis showed that in the HC group, PM acc with positive emotional cues and negative emotional cues were significantly greater than PM acc with neutral emotional cues (Cohen′s d values are 2.29 and 2.94). There was no significant difference between PM acc with positive emotional cues and PM acc with negative emotional cues. In the OCD group, PM acc with negative emotional cues was significantly greater than PM acc with positive and neutral emotional cues (Cohen′s d values are 1.57 and 1.14). There was no significant difference between PM acc with positive emotional cues and PM acc with neutral emotional cues. Correlation analysis showed that PM acc with positive and negative emotional cues of OCD patients were significantly positively correlated with state anxiety level (r>0.200, P<0.01). There was no significant correlation between PM acc with neutral emotional cues and anxiety level. Conclusion OCD patients had impaired prospective memory, mainly manifested as impaired prospective memory emotional enhancement effect, only negative emotion enhancement effect showed. In contrast, positive emotion has no enhancement effect on the prospective memory of OCD patients.
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