Prevalence of Minor 汕-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories

作者：Alireza Moafi; Sadeg Valian; Zahra Nikyar; Mehrdad Zeinalian

来源：International Journal of Hematology-Oncology and Stem Cell Research, 2010.

• Minor &beta
• -Thalassemia
• Screening
• MCH
• MCV
• Thalassemia Preventing Program

%26quot;nAbstract %26quot;nIntroduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for 汕-thalassemia control programs in Iran. %26quot;nMaterials and Methods: 1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. 汕-thalassemia mutations were evaluated. %26quot;nResults: 汕-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with %26quot;n78≒ MCV≒ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH%26lt;26 with MCV%26lt;78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor 汕-thalassemia and educational levels, race and familial relationships. %26quot;nConclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut- off point for the screening of minor 汕-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH %26lt;26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor 汕-thalassemia more accurately. %26quot;n %26quot;nKey words: Minor 汕-Thalassemia, Screening, MCH, MCV, Thalassemia Preventing Program,