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摘要
We investigated the effect of hydroalcoholic extract the Petiveria alliacea root on fetal and placental development female rats pregnancy. Thirty female rats were mated and divided in groups: I - rats treated with placebo and sacrificed on the 7th day; II - rats treated with hydroalcoholic extract and sacrificed on the 7th day; III - rats treated with placebo and sacrificed on the 14th day; IV - rats treated with hydroalcoholic extract and sacrificed on the 14th day; V - rats treated with placebo for analysis of the offspring; VI - rats treated with hydroalcoholic extract for analysis of the offspring. The extract was administered by gavage in the dosage of 18mg/kg body wt., in 5th day of pregnancy. The implantation sites and placenta were fixed in Bouin and processed for the embedding in paraffin. The offspring were weighed, measured and counted. The hydroalcoholic extract of the root of the P. alliacea causes significant reduction in the number of implantation sites, but do not cause histological alterations in these sites and placenta. No alterations in the number, length and weight have been observed in offspring. Our results suggest that the hydroalcoholic extract from the P. alliacea in the dosage of 18mg/kg body wt., administered to female rats, on the 5th day of pregnancy, only cause a retard in the implantation process. Se investigaron los efectos de la extracto hidroalcoh車lico de la ra赤z Petiveria alliacea sobre el desarrollo fetal y placentario en ratas pre adas. Treinta ratas hembras fueron criadas y divididas en grupos: I- Ratas tratadas con placebo y sacrificado en el d赤a 7; II- Ratas tratadas con el extracto hidroalcoh車lico y sacrificadas en el d赤a 7; III- ratas tratadas con placebo y sacrificado el d赤a 14; IV- ratas tratadas con el extracto hidroalcoh車lico y sacrificaron el d赤a 14; V- ratas tratadas con placebo para el an芍lisis de las cr赤as; VI- ratas tratadas con el extracto hidroalcoh車lico para el an芍lisis de las cr赤as. El extracto se administr車 por sonda en dosis de 18mg/kg de peso corporal, en el 5to d赤a de pre ez. Los s赤tios de implantaci車n y la placenta se fijaron en Bouin y se procesaron para la inclusi車n en parafina. Las cr赤as fueron pesadas, medidas y contadas. El extracto hidroalcoh車lico de la ra赤z de P. alliacea provoc車 una reducci車n significativa en el n迆mero de sitios de implantaci車n, pero no causaron alteraciones histol車gicas en estos sitios y la placenta. No se observaron alteraciones en el n迆mero, longitud y peso de las cr赤as. Nuestros resultados sugieren que el extracto hidroalcoh車lico de P. alliacea en la dosis de 18mg/
