Vulvar Intraepithelial Neoplasia (VIN) and Condylomata

作者:Nelson Erin L*; Bogliatto Fabrizio; Stockdale Colleen K
来源:Clinical Obstetrics and Gynecology, 2015, 58(3): 512-525.
DOI:10.1097/GRF.0000000000000132

摘要

Human papillomavirus (HPV) infection of the lower genital tract is common and its effects are variable. The majority of infections are transient and the related pathology is self-resolving. Condyloma accuminatum is caused predominantly by HPV 6, 11 and can be managed with medical or surgical therapy. Vulvar intraepithelial neoplasia is a treatable precursor to vulvar cancer with 2 main forms: one related to HPV and the other to chronic vulvar inflammatory conditions. It may be treated medically, surgically, or potentially via the use of therapeutic HPV vaccines. Preventive utilization of a quadrivalent HPV vaccine has the potential to decrease HPV-related lower genital disease burden substantially.