Synthesis and biological activity of novel 1-(2,3,4-trimethoxyphenyl)-2-{[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiaz ol-2-yl]thio}ethanone oxime ester derivatives

作者：Xue, Wei; Song, Baoan^*; He, Wei; Wang, Hua; Yang, Song; Jin, Linhong; Hu, Deyu; Liu, Gang; Lu, Ping

来源：Journal of Heterocyclic Chemistry, 2006, 43(4): 867-871.

DOI：10.1002/jhet.5570430409

• ORGANIC-REACTIONS

In a search for new fungicide and anticancer agent with improved biological properties and different bioactivity spectrum, we designed and synthesized a series of novel oxime esters containing 1,3,4-thiadiazole group in moderate yield starting from gallic acid. The title compounds were identified by IR, H-1 NMR, C-13 NMR and elemental analysis. The bioassay tests showed that these title compounds exhibit weak to moderate anticancer activity in vitro by MTT method.

• 单位
  贵州大学