Serum Concentrations of TNF 汐 and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery

作者:Jan Komorowski; Jolanta Jurczynska; Tomasz Stepien; Krzysztof Kolomecki; Krzysztof Kuzdak; Henryk Stepien
来源:International Journal of Molecular Sciences, 2010.
DOI:10.3390/ijms11062281

摘要

The peripheral blood levels of TNF 汐 and its soluble receptors were studied in 39 patients with malignant and benign adrenal tumors treated by adrenalectomy. The concentrations of TNF 汐 were significantly elevated in patients with malignant tumors of the adrenal cortex and in patients with Conn%26apos;s syndrome compared to control. In patients with non-functioning adenomas and pheochromocytomas, TNF 汐 levels were similar to those detected in the control. In subjects with myelolipomas, the serum concentration of TNF 汐 was lower compared to the control. After adrenalectomy, the levels of TNF 汐 were decreased in patients with malignant tumors and in patients with Conn%26apos;s syndrome, non-functioniong adenomas and pheochromocytomas compared to the concentration before surgery. The serum concentrations of soluble receptors of TNF 汐 did not differ among different patient groups and compared to the control. After adrenalectomy, the blood concentrations of TNF 汐 R1 and TNF 汐 R2 were decreased in patients with Conn%26apos;s syndrome. However, to confirm practicality of the evaluation of TNF 汐 and its soluble receptors in differential diagnosis in patients with adrenal tumors, a larger study group is needed.

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