摘要

This study analyzed the consequence of malnutrition and/or serotoninergic manipulation during the period of fast growth of encephalon on the somatic development in rats. It was used the protocol of measurement of indicators of this development proposed by Silva et al., 2005. The protocol was applied from 1st to 21st day and rats were breastfed by female which received control diet (commercial diet, Labina) with 23% of protein, normoproteic diet, nourished animals (Group Nourished - Nour), n=15 or were breastfed by female which after the delivery received hypoproteic diet (Regional Basic Diet - RBD), with 8% of protein, malnourished animals (Group Malnourished - Maln) n=15. It were observed in the group malnourished a decrease of corporal weight from 4th day, of latero-lateral axis of skull from 8th to 21st day, of antero-posterior axis of skull from 10th to 21st day, of longitudinal axis and length of tail from 7th to 21st day of life (p 0,05) The study emphasized the hypothesis that malnutrition in critical period of development, interferes on somatic development of rats. Besides that, it was emphasized that the use of protocols with definition of anatomic points and suitable choice of material and accuracy of measurements provide a higher uniformity in periods which were observed the deleterious effects in all studied axes : Evaluamos las repercusiones de la desnutrici車n y/o de la manipulaci車n serotonin谷rgica, durante el per赤odo de crecimiento r芍pido del enc谷falo, en el desarrollo som芍tico en ratas. Para esto, fue utilizado el protocolo de medidas de indicadores de desarrollo propuesto por Silva et al., 2005. El protocolo fue aplicado del 1er al 21 d赤a. Las ratas fueron amamantadas por madres que recibieron dieta controlada (dieta comercial, Labina) normoproteica con 23% de prote赤nas (Grupo Nutrido - Nut), n=15, o fueron amamantados por madres que despu谷s del parto recibieron dieta hipoprot谷ica (Dieta B芍sica Regional - DBR), conteniendo 8% de prote赤na (Grupo Desnutrido - Desn), n=15. En el grupo desnutrido fueron observadas reducciones en el peso corporal a partir del 4 d赤a, en el eje l芍tero-lateral del cr芍neo del 8~ al 21~ d赤a de vida, en el eje 芍ntero-posterior del cr芍neo del 10~ al 21~ d赤a, en el eje longitudinal y en la cola del 7~ al 21~ d赤a (p = 0.05). El estudio ratific車 la hip車tesis que la desnutrici車n, en el per赤odo cr赤tico del desarrollo, interviene con el crecimiento som芍tico de las ratas. Por otra parte, fue comprobado que el uso de protocolos con la definici車n de puntos anat車micos y precisi車n de las medidas, proporcionan una uniformidad e

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