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摘要
OBJECTIVE: Non-small cell lung cancer(NSCLC) is common malignant tumor in the elderly with poor prognosis.This paper explores the prognostic factors to provide evidence for its clinical diagnosis and treatment and prognosis evaluation. METHODS: A total of 124 elderly patients with the first diagnosed NSCLC were retrospectively enrolled from the Sichuan Provincial People's Hospital between January 3 and December 31, 2014.Baseline clinicopathologic characteristics, pretherapeutic laboratory parameters and follow-up information were collected.The survival rate was estimated by Kaplan-Meier estimator, univariable and multivariable COX proportional hazards regression models were applied to detect relationship between clinicopathologic characteristics/pretherapeutic laboratory parameters and survival rate. RESULTS: Based on univariate analysis, age(HR=1.109, P<0.001), ECOG performance status(HR=2.949, P=0.017), NCCN-TNM stage(HR=3.677, P=0.001), tumor number(multiple vs single, HR=3.864, P=0.002), neutrophil counts(HR=1.996, P=0.048), systemic immuneinflammation index(HR=3.635, P=0.008), albumin(ALB)(HR=0.296, P=0.002), and tumor resection(HR=0.223, P=0.001) were related to survival rate.ECOG performance(HR=0.38, P=0.043), NCCN-TNM stage(HR=0.338, P=0.009), tumor number(multiple vs.single) (HR=0.215, P=0.001) and ALB(HR=4.864, P<0.001) were further detected to be related to the survival rate by the multivariable COX model. CONCLUSION: ECOG performance, NCCN-TNM stage, tumor number (multiple vs single) and ALB are interrelated prognostic factors to survival rate.
