科研之友
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摘要
purpose: there are few studies using healing parameters in diabetic animals before the wound, and no studies in the colon. the aim of this study was to verify if alloxan diabetes-induced could primarily change parameters commonly used to measure the small bowel healing in surgical wounded rats, although using animals without any surgical procedure. methods: 180 rats were assigned to in two groups, of non-diabetic control animals, and diabetic animals. the animals were considered diabetics if blood glucose level%26gt;200mg/dl and urinary glucose level%26gt;3000mg/dl. after 3 months, both groups were evaluated in 6 moments of sacrifice, when were analyzed diabetes (blood and urinary glucose levels and plasmatic insulin) and healing in the colon (breaking strength, hydroxyproline, total tissue protein and the ratio ohp/ttp). results: alloxan 2% caused 42,3% of mortality and 72,4% of severe diabetes. all animals in the diabetic group (g2) presented with blood glucose%26gt;300mg/dl and urinary glucose%26gt;3000mg/dl and significant decrease in plasmatic insulin. neither the breaking strength, nor the biochemical dosages (hop, ttp) showed up any meaningful statistical variation between groups. conclusion: the findings of our study suggest that diabetes by itself is not able to change healing parameters, before the surgical injury in the colon of rats.
