Exploration of the role of anti‐Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome

作者：Minh Tam Le; Viet Nguyen Sa Le; Dinh Duong Le; Vu Quoc Huy Nguyen; Chen Chen; Ngoc Thanh Cao

来源：Clinical Endocrinology, 2019, 90(4): 579-585.

DOI：10.1111/cen.13934

• Anti‐Mullerian hormone
• Diagnostic value
• LH/FSH ratio
• Polycystic ovary syndrome

Summary(#br)Objective(#br)This study explores the role of anti‐Mullerian hormone (AMH) and LH/FSH ratio in diagnosis of polycystic ovary syndrome (PCOS).(#br)Methods(#br)In this multicentre cross‐sectional descriptive study, a total of 863 infertile women between 18 and 45 years were evaluated at three infertility centres in Vietnam and were recruited from June 2016 to June 2017. The patients were classified into two groups: Group I included 441 patients with PCOS (based on Rotterdam criteria consensus) and Group II included 422 non‐PCOS women. Diagnosis of PCOS was established based on Rotterdam 2003 consensus, and exclusion criteria were ovarian disease (ovary cyst/tumour), history of ovarian surgery and ovarian failure.(#br)Results(#br)At an optimum cut‐off level of 32.79 pmol/L, AMH showed sensitivity and specificity of 78.50% and 75.83%, respectively, with the AUC 0.852 (95% CI: 0.826‐0.875). The LH/FSH ratio had a similar AUC at the optimum cut‐off of 1.33 (AUC = 0.867, 95% CI 0.842‐0.889), which demons...