科研之友
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摘要
objective: the term of critical ischemia of legs is used in patients with chronical ischemia and pain in rest, ulcer or tisular necrosis secondary to oclussive arterial disease. the objective of our work was to identify factors related with clinical stage and type of surgery in these patients. material and methods: an observational study was performed during two years, from january 1999 to december 2000, with 330 patients with surgery secondary to critical ischemia of legs. the next parameters were recorded during the hospital stance; age, sex, blood pressure, glycaemia, total colesterol, ldl colesterol, hdl colesterol, triglycerides, location of disease, type of surgery, arm-ankle index, and farmacological treatment to cardiovscular risk factors. a regression logistic analyze was realized to study the influence of diferents variables in the clinical stage and in the type of surgery. results: the mean age was 74.78 ㊣ 10.35 years, with a higher age in females (78.88 ㊣ 10.45 years) than males (73.70 ㊣ 10.07) (p %26lt;0,0001), with 261 males (79.1%) and 69 females (20.9%). logistic regression model to investigate clinical stage iii/iv (adjusted by age and sex) showed that the independent variables related with stage iv were diabetes mellitus, location of arterial lesion, and low colesterol levels. a patient with diabetes mellitus type 2 has 3,322 (ci 95%: 1,881-5,866) times more risk of stage iv than a non diabetic patient. odds ratio of total colesterol was 0,990, the risk to develop a iv stage is increased 0,990 times for each mg/dl of cholesterol. distal lesion increased the risk of stage iv en 6,897 times (ci 95%: 3,509 - 13,557). logistic regression model to investigate type of surgery (amputation/bypass) (adjusted by age and sex) showed that diabetes mellitus type 2 had odds ratio (or) of 3,37, this means that diabetes increase 3,37 times (ci 95%: 1,940-5,866) the risk of amputation. total cholesterol showed a or of 0,986, this jeans an increase of amputation 0,986 ti
