LASSBio‐1829 Hydrochloride: Development of a New Orally Active N ‐Acylhydrazone IKK2 Inhibitor with Anti‐inflammatory Properties

作者：Isabella A Guedes; Rosana H C N Freitas; Natália M Cordeiro; Thaís S do Nascimento; Tayna S Valerio; Prof Patrícia D Fernandes; Prof Laurent E Dardenne; Prof Carlos A M Fraga

来源：ChemMedChem, 2016, 11(2): 234-244.

DOI：10.1002/cmdc.201500266

• anti-inflammatory agents
• IKK2
• molecular docking
• N -acylhydrazones
• structure-based drug design

Abstract(#br)Inhibitor of nuclear factor κB kinase 2 (IKK2) is suggested to be a potential target for the development of novel anti‐inflammatory and anticancer drugs. In this work, we applied structure‐based drug design to improve the potency of the inhibitor ( E )‐ N ′‐(4‐nitrobenzylidene)‐2‐naphth...