O uso da associaˋˋo azitromicina e N-metil glucamina no tratamento da leishmaniose cutanea causada por Leishmania (Leishmania) amazonensis em camundongos C57BL6

作者：Sampaio; Raimunda Nonata Ribeiro; Lucas; iris Campos; Costa Filho; Arnoldo Velloso da

来源：Anais Brasileiros de Dermatologia, 2009, 84(2): 125-128.

DOI：10.1590/S0365-05962009000200004

• azythromycin
• leishmaniasis
• cutaneous
• leishmaniasis
• cutaneous [therapy].

background: the first choice treatment for cutaneous leishmaniasis is n-methyl glucamine: it has high toxicity, requires parenteral administration and cure is not always reached. azythromycin showed in vitro action and controversial results in humans with the disease. objective: to verify if the association of n-methyl-glucamine - azythromycin is more effective than n-methyl-glucamine alone for the treatment of experimental leishmaniasis. methods: twenty-five c57bl/6 mice were inoculated with l. (l.) amazonensis strain and divided into two groups. one group was treated with 400mgsbv/kg/day of n-methyl glucamine and 200mg/kg/day of azythromycin for 20 days and the other group received the same dose of n-methyl glucamine alone during the same period of time. clinical and parasitological evaluations were submitted to statistical analyses. results: there was no statistical difference in clinical analysis, in amastigotes investigation and in cultures. there were significant differences in cultures using limiting dilution, which showed lower efficacy of the association n-methyl glucamine -azythromycin. conclusion: n-methyl glucamine-azythromycin association was not more effective than n-methyl glucamine alone.