二咖啡酰奎宁酸类天然产物植物来源、药动学及生物活性的研究进展

作者：Han Ya-Ru; Ma Guo-Li; Han Ya-Long; Gao Jia-Min; She Zhan-Fei; Feng Yu-Bao^*; Xiao Bin

来源：Chinese Traditional and Herbal Drugs, 2023, 54(4): 1285-1298.

DOI：10.7501/j.issn.0253-2670.2023.04.030

• antioxidation
• cardiovascular and cerebrovascular diseases
• development
• dicaffeoylquinic acids
• pharmacokinetics
• plant origin
• utilization

With the continuous improvement of the living standard, high-fat and high-protein diet leading to cancer, cardiovascular and cerebrovascular diseases, and allergic diseases have become the main causes of threats to human health, of which antioxidant and free radical scavenging is one of the important prevention and treatment methods. Dicaffeoylquinic acids are widely distributed in nature, with polyphenol structure and various physiological functions including antioxidant, anti-inflammatory, hypoglycemic, lipid-lowering, platelet inhibitory, antimicrobial and anti-tumor, etc., which have attracted extensive attention from many scholars at home and abroad. Due to the influence of physicochemical properties and pharmacokinetics, its drug development is not perfect. In this paper, the plant origins, pharmacokinetics, and biological activities of natural dicaffeoylquinic acids were reviewed to provide basis for their development and utilization. ? 2023 Editorial Office of Chinese Traditional and Herbal Drugs.