Ky‐2, a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS‐driven human macrophages

作者：Junya Kaneko; Toshinori Okinaga; Wataru Ariyoshi; Hisako Hikiji; Seiko Fujii; Kenjiro Iwanaga; Kazuhiro Tominaga; Tatsuji Nishihara

来源：Cell Biology International, 2018, 42(12): 1622-1631.

DOI：10.1002/cbin.11058

• HDAC inhibitor
• Histone deacetylase
• Inflammasome
• Macrophage polarization
• MAPK

Abstract(#br)Histone deacetylase has attracted much attention as an epigenetic factor, and the modulation of histone and transcription factor acetylation status is important for regulating gene expression. Moreover, histone deacetylase inhibitors are involved in cellular growth and differentiation. ...