科研之友
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摘要
Due to the frequent and extensive use of antibiotics, potential risk have posed to the ecological environment and human. It is of great significance to study its distribution characteristics in water bodies and assess its risk on ecology and human beings. In this paper, the drinking water sample in Dongguan from 11 evaluation sites were collected to investigate the concentrations and distribution of 45 antibiotics in the region using solid phase extraction combined with RRLC-MS/MS. The principal component analysis and pearson correlation analysis were used to analyze the sources of antibiotics, and the potential risks of antibiotics were evaluated by the methods of ecological risk quotient (RQ) and human health risk quotient (HQ). Results showed that a total of 35 antibiotics, accounting for 75.6% of all target antibiotics, were detected in the evaluation samples with a concentration level ranged between ND (undetected)~143.94 ng?L-1 and the highest concentration was oleandomycin. The cumulative contribution rate of the main components was 63.5%, and the pollution sources of sulfadiazine, sulfamonomethoxine, pefloxacin, and carbadox were initially established in connection with sewage treatment plants. The ecological risk assessment indicated that the high-risk antibiotics were clarithromycin>novobiocin>norfloxacin, and RQ value of clarithromycin could reach up to 4.78, which appeared in Shilong west lake, and the average RQ value of novobiocin was 1.15. Health risk assessment of people in different ages indicated that the detected antibiotics posed no risk to human body, but it should still attract attention to the potential risk caused by the cumulative effect.
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