科研之友
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摘要
objective: to identify the role of bronchodilators in the maximal breath-hold time in patients with obstructive lung disease (old). methods: we conducted a case-control study including patients with old and a control group. spirometric tests were performed prior to and after the use of a bronchodilator, as were breath-hold tests, using an electronic microprocessor and a pneumotachograph as a flow transducer. respiratory flow curves were displayed in real time on a portable computer. the maximal breath-hold times at end-inspiratory volume and at end-expiratory volume (bhtmaxvei and bhtmaxvee, respectively) were determined from the acquired signal. results: a total of 35 patients with old and 16 controls were included. prior to the use of a bronchodilator, the bhtmaxvei was significantly lower in the old group than in the control group (22.27 ㊣ 11.81 s vs. 31.45 ㊣ 15.73 s; p = 0.025), although there was no significant difference between the two groups in terms of the post-bronchodilator values (24.94 ㊣ 12.89 s vs. 31.67 ㊣ 17.53 s). in contrast, bhtmaxvee values were significantly lower in the old group than in the control group, in the pre- and post-bronchodilator tests (16.88 ㊣ 6.58 s vs. 22.09 ㊣ 7.95 s; p = 0.017; and 21.22 ㊣ 9.37 s vs. 28.53 ㊣ 12.46 s; p = 0.024, respectively). conclusions: our results provide additional evidence of the clinical usefulness of the breath-hold test in the assessment of pulmonary function and add to the existing knowledge regarding the role of the bronchodilator in this test.
