Implicaci車n de la IL-6 y su polimorfismo -174G%26gt;C en el control del peso corporal y en las complicaciones metab車licas asociadas a la obesidad

作者：Goyenechea; E; Parra; M D; Martinez Hernandez; J A

来源：Anales del Sistema Sanitario de Navarra, 2005.

DOI：10.4321/S1137-66272005000500007

• il-6
• obesity
• diabetes
• polymorphism
• high blood pressure.

obesity and its comorbidities have been associated with a low grade proinflammatory state, in which the adipose tissue seems to be involved. in fact, this tissue produces different proinflammatory cytokines, such as il-6 and others. high circulating concentrations of il-6 have been related to high body mass index, to diabetes mellitus type 2, to lipid abnormalities and to high blood pressure. there are some studies, which reported a relationship between il-6 and energy metabolism, so this cytokine and its -174gc gene polymorphism could be factors involved in the development of obesity. different studies have associated the g allele of the il-6 gene with obesity, with insulin resistance and with different cardiovascular risk factors. however, other published reports have associated the c allele of this gene to these metabolic disturbances and pathologies. this paper reviews recently published evidences about il-6 and its physiopathological involvement in obesity and comorbidities, with emphasis on the role of the -174gc polymorphism in the aetiology of these disturbances, in which obesity is a major risk factor.