科研之友
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摘要
The minor salivary glands are found scattered throughout the oral mucosa, especially in the lips and soft palate mucosa. Several factors can cause xerostomia, whereas the salivary glands histological characteristics are also considered as factors for defining the etiology. Thus, the minor salivary glands biopsy represents an essential tool for attending the required diagnosis criterion in the classification of Sj gren%26apos;s Syndrome patients, since it does not present risk for the patient. The objective of this study is to determine the histological description of the minor salivary glands obtained from the biopsies of xerostomia patients and to classify the minor salivary gland histological aspect as the Sj gren%26apos;s Syndrome. Forty laminas of xerostomia patients that were submitted to minor salivary glands biopsy at the Santa Casa de Sao Paulo Stomatology ambulatory were retrospectively studied. The variation in the glands histological aspect was observed, from the normality up to the presence of inflammatory focus, replacing the conjunctive between acini and ducts, as well as the parenchyma. In 15 cases, the infiltrated inflammatory cells amounted to focus, that is to say, groups of at least 50 inflammatory cells around the acini or ducts, which is a characteristic aspect of the Sj gren%26apos;s Syndrome. Therefore, the finding of at least one inflammatory focus of 4 mm2 of glandular tissue represents a set criterion, although, not the only one in order to classify this patient as having the Sj gren%26apos;s Syndrome Las gl芍ndulas salivales menores son encontradas distribuidas a trav谷s de la mucosa oral, especialmente en los labios y en la mucosa del paladar blando. Varios factores pueden causar xerostom赤a, donde las caracter赤sticas histol車gicas de las gl芍ndulas salivales son tambi谷n consideradas como factores para definir la etiolog赤a. As赤, las biopsias de las gl芍ndulas salivales menores representan una herramienta fundamental para alcanzar los criterios diagn車sticos requeridos en la clasificaci車n de pacientes con s赤ndrome de Sj gren, ya que no representa riesgo para los pacientes. El objetivo de este estudio es determinar las caracter赤sticas histol車gicas de las gl芍ndulas mencionadas, obtenidas de biopsias de pacientes con xerostom赤a y clasificar los aspectos histol車gicos de las gl芍ndulas en el s赤ndrome de Sj gren. Estudiamos 40 l芍minas de pacientes con xerostom赤a, cuyas gl芍ndulas salivales menores fueron sometidas a biopsia en el Servicio de Estomatolog赤a de la Santa Casa de S o Paulo, Brasil. Se observaron las variaciones de su aspecto histol車gico, desde la normalidad
