Construction of a 980 nm laser-activated Pt(Ⅱ) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

作者：Yuling Xu; Chonglu Li; Jusung An; Xin Ma; Jingfang Yang; Lishi Luo; Yun Deng; Jong Seung Kim^*; Yao Sun^*

来源：Science China Chemistry, 2023, 66(01): 155-163.

Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult.We therefore synthesized a novel Pt(Ⅱ) metallacycle(Pt1110) that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue.We found that Pt1110 significantly improved photothermal conversion(95% improvement) and 1O2 generation(ΦΔ 75% increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm2).In addition,Pt1110 has little to no toxicity to cells.After incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱ fluorescence imaging.This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.

• 单位
  化学生物传感与计量学国家重点实验室; 华中师范大学