2022年全国认知、衰老及其相关疾病学术会议摘要

来源：神经药理学报, 2022, 12(05): 24-62.

<正>中国·厦门GJ-4 Alleviates Memory Deficiency of Vascular Dementia in Rats through PERK-Mediated Endoplasmic Reticulum Stress PathwayYUAN Fang-yu1,NING Jing-wen1,YANG Yang1,LI Gen1,LIU Hui2,ZANG Cai-xia1,BAO Xiu-qi1,*,ZHANG Dan1,*1.State Key Laboratory of Bioactive Substrate and Function of Natural Medicine,Institute of Materica Medica,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,100050,China2.College of Biology and Brewing Engineering,Taishan University,Taian,271000,China【ABSTRACT】Background:Vascular dementia(VD) is a cognitive impairment syndrome caused by a series of cerebrovascular factors,which cause blood circulation disorders and impaired brain function,leading to VD eventually. The number of patients worldwide is estimated to reach 12.3 million by 2030and 22.8 million by 2050. Damage in various brain regions could cause different symptoms except cognitive declines,such as changes in personality or problems with language. Gardenia jasminoides J.Ellis.isatraditionalChinesemedicine,whichnotonlyhasantioxidative,anti-inflammatoryand antibacterialeffects,butalsohasprotectiverolesondigestivesystemandischemia-relatedbrain damage. GJ-4 is extracted from the fruit of Gardenia jasminoides J. Ellis. and it could alleviate memory deficiency in Alzheimer’s disease animal models in our previous studies. The present experiment was designed to evaluate the therapeutic effects of GJ-4 on permanent bilateral common carotid arteries occlusion(2-VO) induced VD rats and elucidate the underlying mechanisms both in vivo and in vitro.