Utilization of Metal Halide Species Ambiguity to Develop Amorphous, Stabilized Pharmaceutical Agents As Ionic Liquids

作者:Lovejoy Katherine S; Corley Cynthia A; Cope Emily K; Valentine Michael C; Leid Jeff G; Purdy Geraldine M; Wilkes John S; Koppisch Andrew T; Del Sesto Rico E*
来源:Crystal Growth & Design, 2012, 12(11): 5357-5364.
DOI:10.1021/cg300969u

摘要

A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.