科研之友
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摘要
Propolis, an apitherapic product widely employed in natural medicine, presents various biological properties, such as bactericidal and anti-inflammatory activities, but only few reports have looked at the Brazilian red propolis variety. Collagen films have been employed to improve wound healing and some studies have investigated the effect of natural products incorporated into these films. Thus, the aim of this study was to analyze the effect of collagen-based films containing red propolis on wound healing. Therefore, wounds performed in the back of rats were dressed with collagen-based films (G2), and collagen-based films containing red propolis (G3); undressed worked as control (G1). After 3, 7 and 14 days the animals were euthanized, and the wounds were microscopically evaluated. In 7 days, G3 showed switch of the inflammatory profile from acute into chronic, increased plasma cells differentiation, replacement of Type-III for type-I collagen fibers, and better architectural organization of those fibers. Furthermore, a slight tendency for a better epithelization was verified in G3, but it was not statistically significant. Also in 7 days, the microvessels count was higher in G1 than in G2 (p=0.000) and G3 (p=0.001), but similar between the last groups (p=0,15), whereas the microvessels perimeter was higher in G1 than in G2 (p=0.000) and G3 (p=0.002), but equivalent in G2 and G3 (p=0.175) in 14 days. In conclusion, the incorporation of Brazilian red propolis into collagen-based films was able to improve wound healing, probably by modulating the dynamics of the inflammatory evolution and collagen deposition process. El prop車leo es un producto apiter芍pico ampliamente usado en medicina natural, que presenta diversas propiedades biol車gicas, como actividad bactericida y anti-inflamatoria, pero pocos informes han examinado la variedad brasile a del prop車leo rojo. Pel赤culas de col芍geno han sido empleadas para mejorar la cicatrizaci車n de heridas y en algunos estudios se ha investigado el efecto de los productos naturales incorporados en estas pel赤culas. As赤 el objetivo de este estudio fue analizar el efecto de las pel赤culas a base de col芍geno que contienen prop車leo rojo en la cicatrizaci車n de heridas. Heridas realizadas en el dorso de ratas fueron revestidas con pel赤culas a base de col芍geno (G2) y con pel赤culas a base de col芍geno con prop車leo rojo (G3), heridas sin revestimiento fueron utilizadas como control (G1). Despu谷s de 3, 7 y 14 d赤as, las heridas fueron evaluadas microsc車picamente. A los 7 d赤as G3 mostr車 un cambio del perfil de la respuesta inflamatoria
