Research progress in the mechanisms of DNA damage response in cell senescence and carcinogenesis [DNA损伤应答与细胞老化及癌变机制研究进展]

作者：He L.-P.; Ning X.-L.; Sun Y.; Hu J.-D.; Liu H.; Qiu X.-H.; Zhou C.-S.^*

来源：Chinese Journal of Cancer Prevention and Treatment, 2017, 24(11): 783-787.

• DNA damage
• Inositol phosphate
• Review literaure
• Senescence
• Tumorigenesis

OBJECTIVE DNA damage is the main cause of cell senescence and tumorigenesis, which is closely related to carcinogenesis. This study aims to summarize the mechanisms of DNA damage response and inositol phosphate biosynthesis pathway in cell senescence and tumorigenesis.METHORDS We retrieved the papers published from January 2000 to July 2016 with key words including tumor, DNA damage, senescence and inositol phosphate from PubMed, CNKI and Wanfang Data, 42 papers were collected by the following criteria: (1) investigated the relationship between DNA damage and senescence or tumor. (2) related to the regulation of senescence and tumor through inositol phosphate biosynthesis. (3) discussed the senescent phenotypes and its causal mechanisms.RESULTS DNA damage mainly regulates senescence and tumor progression through p53/p21, p16INK4a/pRB, GATA4 signaling pathways. Molecules involved in inositol phosphate biosynthesis such as, IP6, IP7, IP6K, also play roles in cell senescence and tumor progression. Cell senescence can not only inhibit but also promote the occurrence of tumor.CONCLUSIONS DNA damage response and inositol phosphate biosynthesis regulate senescence and tumor development through various mechanisms. These findings offer new drug targets for tumor prevention and treatment.