Potencial hidrogeniˋnico de soluˋˋes de cloridrato de dobutamina expostas a condiˋˋes ambientais de unidades de cuidados intensivos neonatais

作者：Reis; Lidiane L; Peterlini; Maria Angelica S; Pedreira; Mavilde L G

来源：Jornal de Pediatria, 2009, 85(6).

DOI：10.1590/S0021-75572009000600014

• neonatal nursing
• intensive care
• drug stability
• dobutamine
• intravenous infusions
• medication errors.

objective: to verify the hydrogen-ion potential (ph) of dobutamine hydrochloride solutions under environmental conditions similar to those of neonatal intensive care units. methods: we analyzed the ph of the drug diluted in 5% dextrose in water or 0.9% nacl under different conditions of temperature (22 and 37 ～c) and light (dark, fluorescent light bulbs, and phototherapy equipment), using colorless and amber intravenous sets at time intervals of 0, 1, 24, 48, 72, and 96 hours. results: the ph values of the marketed form of the drug and the diluted drug were similar. the ph means were 3.45㊣0.19 at 22 ～c and 3.55㊣0.20 at 37 ～c. the average of the ph according to light conditions were as follows: in the dark = 3.62㊣0.09, under room light = 3.63㊣0.07, and exposed to phototherapy = 3.31㊣0.16. solutions stored in colorless intravenous sets had a lower mean (3.41㊣0.24) than those kept in amber intravenous sets (3.52㊣0.15). we found lower ph values in the solutions exposed to phototherapy using colorless intravenous sets (3.17㊣0.03) than in those using amber intravenous sets (3.55㊣0.03). conclusion: there was higher variation in the ph of the solutions exposed to phototherapy, and the use of amber intravenous sets reduced such effect.